Journal article
Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection
AIDS (London), v 25(4), pp 525-529
20 Feb 2011
PMID: 21178753
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Metabolic complications, including type 2 diabetes mellitus and metabolic syndrome, are increasingly recognized among HIV-infected individuals. Low vitamin D levels increase the risk of type 2 diabetes mellitus, and vitamin D supplementation has been shown to decrease the risk of type 2 diabetes mellitus in patients without HIV infection.
Objectives: The primary objective was to determine whether vitamin D deficiency (serum 25-hyrdoxyvitamin D < 20 ng/ml) was associated with type 2 diabetes mellitus among HIV-infected patients. Our secondary objective was to determine whether vitamin D deficiency was associated with metabolic syndrome in HIV.
Methods: We conducted a cross-sectional study among participants enrolled in the prospective Modena (Italy) HIV Metabolic Clinic Cohort. Clinical and laboratory data, including history of type 2 diabetes mellitus, fasting blood glucose, components of metabolic syndrome, and 25-hydroxyvitamin D levels, were obtained for all participants.
Results: After adjusting for vitamin D supplementation, sex, age, body mass index, and hepatitis C virus co-infection, vitamin D deficiency was associated with type 2 diabetes mellitus [adjusted odds ratio (OR) 1.85; 95% confidence interval (CI) 1.03-3.32; P = 0.038]. The association between vitamin D deficiency and metabolic syndrome was not significant after adjusting for vitamin D supplementation, sex, age and body mass index (adjusted OR 1.32; 95% CI 1.00-1.75; P = 0.053).
Conclusions: Our study demonstrates an association between vitamin D deficiency and type 2 diabetes mellitus. Clinical trials are needed to better characterize the association between vitamin D deficiency and type 2 diabetes mellitus in HIV infection and to evaluate whether vitamin D is able to prevent or delay the onset of type 2 diabetes mellitus. (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
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Details
- Title
- Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection
- Creators
- Zsofia Szep - University of PennsylvaniaGiovanni Guaraldi - University of Modena and Reggio EmiliaSamir S. Shah - University of PennsylvaniaVincent Lo Re - Biostat (United States)Sarah J. Ratcliffe - University of PennsylvaniaGabriella Orlando - University of Modena and Reggio EmiliaFederica Carli - University of Modena and Reggio EmiliaRosario Rossi - University of Modena and Reggio EmiliaVincenzo Rochira - University of Modena and Reggio EmiliaPablo Tebas - College Station Medical Center
- Publication Details
- AIDS (London), v 25(4), pp 525-529
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Grant note
- T32AI007001 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32 AI055435-06; K01 AI73729; K01 AI07001 / National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) AI069467 / AIDS Clinical Trial Group, National Institute of Health Robert Wood Johnson Foundation; Robert Wood Johnson Foundation (RWJF) P30 AI 045008 / Penn Center for AIDS Research
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000286970300015
- Scopus ID
- 2-s2.0-79951516278
- Other Identifier
- 991021962287404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Virology