Journal article
Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial
The American journal of clinical nutrition, v 97(3), pp 637-645
01 Mar 2013
PMID: 23364004
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Weight loss (WL) is associated with a decrease in calcium absorption and may be one mechanism that induces bone loss with weight reduction.
Objective: Because vitamin D supplementation has been shown to increase true fractional calcium absorption (TFCA), the goal of this study was to examine the effect of vitamin D during WL or weight maintenance (WM).
Design: A randomized, placebo-controlled, double-blind 6-wk study was conducted in 82 postmenopausal women [BMI (in kg/m(2); +/- SD): 30.2 +/- 3.7] with 25-hydroxyvitamin D [25(OH)D] concentrations <70 nmol/L during either WL or WM. All women were given 10 mu g vitamin D-3/d and 1.2 g Ca/d and either weekly vitamin D-3 (375 mu g) or a placebo equivalent to 63 mu g (2500 IU)/d and 10 mu g (400 IU)/d, respectively. We measured TFCA with the use of dual-stable isotopes, 25(OH)D, parathyroid hormone, estradiol, calcitriol, and urinary calcium at baseline and 6 wk in weight loss and vitamin D-3-supplementation (WL-D; n = 19), weight maintenance and vitamin D-3-supplementation (WM-D; n = 20), weight loss and placebo (n = 22), and weight maintenance and placebo (n = 21) groups.
Results: WL groups lost 3.8 +/- 1.1% of weight with no difference between vitamin D-3 supplementation and the placebo. The rise in serum 25(OH)D was greatest in the WL-D group (19.8 +/- 14.5 nmol/L) compared with in WM-D (9.1 +/- 10.3 nmol/L) and placebo groups (1.5 +/- 10.9 nmol/L). TFCA increased with vitamin D-3 supplementation compared with placebo treatment (P < 0.01) and decreased during WL compared with WM. Serum 25(OH)D or 1,25-dihyroxyvitamin D did not correlate with TFCA.
Conclusion: These data show that vitamin D supplementation increases TFCA and that WL decreases TFCA and suggest that, when calcium intake is 1.2 g/d, either 10 or 63 mu g vitamin Did is sufficient to maintain the calcium balance. This trial was registered at clinical-trials.gov as NCT00473031. Am J Clin Nutr 2013;97:637-45.
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Details
- Title
- Vitamin D supplementation and calcium absorption during caloric restriction: a randomized double-blind trial
- Creators
- Sue A. Shapses - University of Medicine and Dentistry of New JerseyDeeptha Sukumar - Rutgers, The State University of New JerseyStephen H. Schneider - University of Medicine and Dentistry of New JerseyYvette Schlussel - Rutgers, The State University of New JerseyRobert M. Sherrell - University of Medicine and Dentistry of New JerseyM. Paul Field - University of Medicine and Dentistry of New JerseyHasina Ambia-Sobhan - University of Medicine and Dentistry of New Jersey
- Publication Details
- The American journal of clinical nutrition, v 97(3), pp 637-645
- Publisher
- AMER SOC NUTRITION-ASN
- Number of pages
- 9
- Grant note
- R01AG012161 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01 AG12161 / NIH Office of Dietary Supplements (NIH) BBGP201095157 / Busch Biomedical Award National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nutrition Sciences
- Web of Science ID
- WOS:000315431000023
- Scopus ID
- 2-s2.0-84874304826
- Other Identifier
- 991019231748804721
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- Web of Science research areas
- Nutrition & Dietetics