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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Vitamin D supplementation during short-term caloric restriction in healthy overweight/obese older women: Effect on glycemic indices and serum osteocalcin levels
Molecular and cellular endocrinology, v 410(C)
15 Jul 2015
PMID: 25576857
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•We examined vitamin D3 supplementation (VitD) on glycemic indices and osteocalcin.•Women were assigned to weight loss or maintenance and 2500 or 400 IU/d VitD for 6 weeks.•The change in serum osteocalcin was explained by changes in 25OHD and insulin.•VitD and caloric restriction influences osteocalcin and favors insulin sensitivity.
The effect of vitamin D supplementation and caloric restriction (CR) on glycemic indices and osteocalcin (OC) is not clear. In this randomized controlled double blind trial, we examined whether vitamin D3 supplementation at 2500 IU/d (D) or placebo has differential effects on markers of insulin sensitivity and bone turnover in overweight/obese postmenopausal women during 6 weeks of caloric restriction (weight loss; WL, n = 39) compared to weight maintenance (WM, n = 37). Seventy-six women (57 ± 6 years) completed this study and the WL groups lost 4 ± 1% of body weight. Baseline serum 25-hydroxyvitamin D (25OHD) was 24.8 ± 5.6 ng/mL at baseline; the rise was greatest in WL-D group (p < 0.05). There was an interaction between vitamin D intake and weight on serum OC, insulin, glucose and markers of insulin sensitivity (p < 0.05). The change in OC was explained by changes in serum 25OHD and insulin (model R2 = 25.6%). Overall, vitamin D supplementation and CR influence serum osteocalcin levels and modestly favor improvements in insulin sensitivity.
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Details
- Title
- Vitamin D supplementation during short-term caloric restriction in healthy overweight/obese older women: Effect on glycemic indices and serum osteocalcin levels
- Creators
- D. Sukumar - Drexel UniversityS.A. Shapses - Rutgers, The State University of New JerseyS.H. Schneider - Rutgers, The State University of New Jersey
- Publication Details
- Molecular and cellular endocrinology, v 410(C)
- Publisher
- Elsevier Ireland Ltd
- Grant note
- RO1-AG12161; NJAES-0153866 / National Institutes of Health (http://dx.doi.org/10.13039/100000002)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nutrition Sciences
- Web of Science ID
- WOS:000356207800010
- Scopus ID
- 2-s2.0-84930083589
- Other Identifier
- 991019168172104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Endocrinology & Metabolism