Journal article
Vitamin D supplementation, the metabolic syndrome and oxidative stress in obese children
Journal of pediatric endocrinology & metabolism : JPEM, v 30(4), pp 383-388
01 Apr 2017
PMID: 27977406
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previous studies suggest that vitamin D may play a role in cardiovascular and metabolic health. Oxidative stress has also been implicated in the development of cardiovascular disease. Evidence suggests that vitamin D deficiency may contribute to the occurrence of oxidative stress. This study aimed to determine whether treatment and correction of vitamin D deficiency in obese children led to changes in their metabolic profile, independent of changes in adiposity. In addition, we aimed to determine whether vitamin D deficiency and oxidative stress are causally related in obese children.
In the retrospective arm, chart review identified 32 obese children who experienced normalization of vitamin D deficiency or insufficiency with vitamin D supplementation. We then correlated laboratory and anthropometric data with vitamin D levels. In the prospective arm of the study, urinary 8-isoprostane and hydrogen peroxide were measured before and after correction of vitamin D deficiency/insufficiency and correlated to vitamin D levels in seven patients.
In our predominantly Hispanic population of obese children in an urban setting, we demonstrated a cause-effect relationship between vitamin D deficiency and oxidative stress. In contrast, we found no association between vitamin D status, adiposity, and markers of insulin sensitivity, nor any effect of vitamin D treatment on the same parameters.
These discordant findings suggest a differential effect of vitamin D on cardiovascular risk factors such as oxidative stress and insulin resistance. To confirm these findings, further prospective studies with larger sample size and longer follow-up are warranted.
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Details
- Title
- Vitamin D supplementation, the metabolic syndrome and oxidative stress in obese children
- Creators
- Tal Grunwald - St. Christopher's Hospital for ChildrenShruti Fadia - St. Christopher's Hospital for ChildrenBruce Bernstein - St. Christopher's Hospital for ChildrenMatthew Naliborski - St. Christopher's Hospital for ChildrenShufang Wu - St. Christopher's Hospital for ChildrenFrancesco De Luca - Department of Pediatrics, Section of Endocrinology and Diabetes, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PAFrancesco DeLuca - Pediatrics
- Publication Details
- Journal of pediatric endocrinology & metabolism : JPEM, v 30(4), pp 383-388
- Publisher
- De Gruyter
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine
- Web of Science ID
- WOS:000400460100003
- Scopus ID
- 2-s2.0-85017365415
- Other Identifier
- 991019168717004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Pediatrics