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Journal article
Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18-65 Years: Findings from 2007-2018 NHANES
Toxics (Basel), v 13(1), p9
25 Dec 2024
PMID: 39853009
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
The association between heavy metal exposure and diabetes is controversial and vitamin E (VE) may reduce diabetes risk. We aimed to examine the associations between blood heavy metals (BHMs) and diabetes risk and VE's role in the relationship. From the 2007-2018 NHANES, 10,721 participants aged ≥ 18 were included for multiple statistical analyses, which revealed that BHMs and dietary VE intake were negatively associated with diabetes and fasting plasma glucose (FPG). The diabetes prevalence in each quartile (Q) of heavy metal exposure increased with age, but within age Q4, it generally decreased with exposure quartiles. Moreover, BHMs were positively associated with all-cause and diabetes-related mortalities with aging, which induced an age breakpoint of 65 years for age-stratified analyses on the associations between BHMs and diabetes risk. In those aged > 65, BHMs were negatively correlated with diabetes risk and its biomarkers; however, in adults aged 18-65, the correlation was positive. At higher VE intake levels, blood lead was associated with a lower diabetes risk and all three BHMs demonstrated lower FPG levels than those at lower VE intake levels. In conclusion, consuming sufficient VE and avoiding heavy metal exposure are highly recommended to reduce diabetes risk.
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- Title
- Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18-65 Years: Findings from 2007-2018 NHANES
- Creators
- Chenggang Yang - Sun Yat-sen UniversityShimiao Dai - Sun Yat-sen UniversityYutian Luo - Columbia UniversityQingqing Lv - Sun Yat-sen UniversityJunying Zhu - Sun Yat-sen UniversityAolin Yang - Sun Yat-sen UniversityZhan Shi - Sun Yat-sen UniversityZiyu Han - Sun Yat-sen UniversityRuirui Yu - The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, ChinaJialei Yang - Sun Yat-sen UniversityLongjian Liu (Corresponding Author) - Drexel University, Urban Health CollaborativeJi-Chang Zhou - Sun Yat-sen University
- Publication Details
- Toxics (Basel), v 13(1), p9
- Publisher
- MDPI
- Grant note
- GJHZ20240218114600001 / Science, Technology and Innovation Commission of Shenzhen Municipality, China 81973038 / National Natural Science Foundation of China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001404923400001
- Scopus ID
- 2-s2.0-85215812621
- Other Identifier
- 991022008296704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Toxicology