Journal article
Von-Willebrand Factor Influences Blood Brain Barrier Permeability and Brain Inflammation in Experimental Allergic Encephalomyelitis
The American journal of pathology, v 173(3), pp 892-900
Sep 2008
PMID: 18688020
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Weibel-Palade bodies within endothelial cells are secretory granules known to release von Willebrand Factor (VWF), P-selectin, chemokines, and other stored molecules following histamine exposure. Mice with a disrupted VWF gene (VWFKO) have endothelial cells that are deficient in Weibel-Palade bodies. These mice were used to evaluate the role of VWF and/or Weibel-Palade bodies in
Bordetella pertussis
toxin-induced hypersensitivity to histamine, a subphenotype of experimental allergic encephalomyelitis, the principal autoimmune model of multiple sclerosis. No significant differences in susceptibility to histamine between wild-type and VWFKO mice were detected after 3 days; however, histamine sensitivity persisted significantly longer in VWFKO mice. Correspondingly, encephalomyelitis onset was earlier, disease was more severe, and blood brain barrier (BBB) permeability was significantly increased in VWFKO mice, as compared with wild-type mice. Moreover, inflammation was selectively increased in the brains, but not spinal cords, of VWFKO mice as compared with wild-type mice. Early increases in BBB permeability in VWFKO mice were not due to increased encephalitogenic T-cell activity since BBB permeability did not differ in adjuvant-treated VWFKO mice as compared with littermates immunized with encephalitogenic peptide plus adjuvant. Taken together, these data indicate that VWF and/or Weibel-Palade bodies negatively regulate BBB permeability changes and autoimmune inflammatory lesion formation within the brain elicited by peripheral inflammatory stimuli.
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Details
- Title
- Von-Willebrand Factor Influences Blood Brain Barrier Permeability and Brain Inflammation in Experimental Allergic Encephalomyelitis
- Creators
- Rajkumar Noubade - From the Department of MedicineRoxana del Rio - From the Department of MedicineBenjamin McElvany - From the Department of MedicineJames F Zachary - From the Department of MedicineJason M Millward - From the Department of MedicineDenisa D Wagner - From the Department of MedicineHalina Offner - From the Department of MedicineElizabeth P Blankenhorn - From the Department of MedicineCory Teuscher - From the Department of Medicine
- Publication Details
- The American journal of pathology, v 173(3), pp 892-900
- Publisher
- American Society for Investigative Pathology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000258921900027
- Scopus ID
- 2-s2.0-51349102183
- Other Identifier
- 991014877831204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pathology