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Weight Loss Intervention in Survivors of ER/PR-negative Breast Cancer
Journal article   Open access   Peer reviewed

Weight Loss Intervention in Survivors of ER/PR-negative Breast Cancer

Mara Z Vitolins, Brandy-Joe Milliron, Judith O Hopkins, Artie Fulmer, Julia Lawrence, Susan Melin and Douglas Case
Clinical medicine insights. Women's health, v 7(2014), pp 17-24
16 Jun 2014
DOI: https://doi.org/10.4137/CMWH.S13955
PMID: 24987274
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.4137/cmwh.s13955View
Published, Version of Record (VoR)CC BY-NC V4.0,  Open
url
https://doi.org/10.4137/CMWH.S13955View
Published, Version of Record (VoR) Open

Abstract

estrogen negative breast cancer meal replacement nutrition intervention Original Research weight loss
Numerous studies have found that increased body size (weight or body mass index) is a risk factor for breast cancer development, recurrence, and death. The detrimental relationship between body size and breast cancer recurrence may be more pronounced among women with estrogen receptor (ER)/progesterone receptor (PR)-negative breast cancer. Considering the limited availability of treatments, and the association between body size and recurrence, alternative treatments are needed for ER/PR-negative breast cancer survivors, particularly overweight survivors. The objective of this pilot study was to examine the feasibility of a 12-week, multi-component meal-replacement weight loss intervention among overweight or obese ER/PR-negative breast cancer survivors; and to obtain preliminary data on changes in anthropometrics, biomarkers, and health-related quality of life (QOL). The 12-week intervention included a portion-controlled diet (including meal replacements) and a multi-component intervention (including behavioral techniques, diet modification, physical activity, and social support). The goal of the intervention was to help participants lose 5% or more of their initial weight by reducing their caloric intake and increasing their physical activity (to at least 15 minutes each day). Paired t -tests assessed changes in continuous measures. Body weight was measured weekly and mixed-model regression analysis assessed change in weight over time. Nineteen ER/PR-negative breast cancer survivors with a mean age of 59 years participated in the study. All but two of the participants completed the 12-week intervention. Women lost an average of 6.3 ± 4.9 kg ( P < 0.001), equivalent to 7.5% of their baseline weight. There were significant reductions in waist circumference ( P = 0.001), percent fat mass ( P < 0.001), total cholesterol ( P = 0.026), and triglycerides ( P = 0.002); and improvements in health-related QOL ( P = 0.017). Findings suggested that a meal-replacement weight loss approach among ER/PR-negative breast cancer survivors was feasible and was well received.

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6 citations in Web of Science

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Obstetrics & Gynecology
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