Journal article
What counts as 'rest'?: Low-frequency correlations within the medial temporal lobe during an unrelated task predict memory
Journal of Cognitive Neuroscience. Supplement, pp.228d-228d
01 Jan 2013
Abstract
Previous investigations of resting connectivity have shown that low frequency correlations within the medial temporal lobe (MTL) can predict individual differences in performance on standardized memory tasks (Wig et al., 2008). However, it is unclear whether MTL correlations during an unrelated cognitive task, where the MTL may act as if at rest, are also related to memory performance. We used hi-resolution fMRI to investigate whether MTL connectivity during a math task predicts associative memory for object-pairs presented in a separate block. Subjects first completed a 'baseline' math task, and then performed 4 runs comprised of blocks of encoding, more math, and retrieval. During the encoding block, subjects were asked to form vivid mental images of pairs of objects. They then solved a block of math problems, and then performed a cued recall task for the object associations. Long-term item and associative memory was also tested after a 24-hr delay. Preliminary results show that individual differences in connectivity between parahippocampal cortex and hippocampal subregions during the baseline math task predict long-term item memory, while connectivity between CA3 and MTL cortical areas predicts immediate associative memory. Given that recent work has provided evidence for enhanced resting connectivity after learning (Albert et al., 2009), and shown that post-encoding resting connectivity predicts memory (Tambini and Davachi, 2010), further analysis will investigate how changes in hippocampal-cortical connectivity during post-encoding math predicts memory. Representation similarity analysis will also be used to characterize the activity of MTL regions as they relate to memory.
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Details
- Title
- What counts as 'rest'?: Low-frequency correlations within the medial temporal lobe during an unrelated task predict memory
- Creators
- Alexa TomparyKatherine DuncanLila Davachi
- Publication Details
- Journal of Cognitive Neuroscience. Supplement, pp.228d-228d
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychology
- Identifiers
- 991021463532604721