Journal article
What is the value of preoperative prophylactic heparin in reducing venous thromboembolism in major non-cardiac thoracic surgery?
The American journal of surgery, v 224(4), pp 1086-1089
01 Oct 2022
PMID: 35660085
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Studies have investigated the utility of preoperative heparin to mitigate venous thromboembolism risk after surgery. However, whether heparin reduces the risk of VTE following major thoracic surgery is un-determined. A national heparin shortage beginning in September 2019 provided the opportunity for a natural experiment to explore this question.
Methods: A retrospective analysis was conducted including all major thoracic surgery cases at a single center from March 2019 to April 2020. The primary outcome was VTE. Two sample t-tests, Chi-Square analyses, and multivariable regressions were performed.
Results: The study consisted of 890 patients, 391 before the heparin shortage and 499 afterwards. 398 total patients received heparin, 340 before the heparin shortage and 58 afterwards. On univariate analyses, there was no association between VTE and preoperative heparin (p > 0.90). This remained consistent on multivariable analyses (p > 0.1).
Conclusion: In this single center analysis, there was no association between preoperative heparin and the occurrence of postoperative VTE. Analyses in larger cohorts will provide additional evidence to guide policies on the use of preoperative prophylactic heparin.
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Details
- Title
- What is the value of preoperative prophylactic heparin in reducing venous thromboembolism in major non-cardiac thoracic surgery?
- Creators
- Niyi Odewade - Harvard UniversityNosayaba Enofe - Drexel UniversityMonica Soni - Georgetown UniversityStanley Wolfe - Massachusetts General HospitalChi-Fu Yang - College Station Medical CenterAsishana Osho - Massachusetts General Hospital
- Publication Details
- The American journal of surgery, v 224(4), pp 1086-1089
- Publisher
- Elsevier
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000890655200001
- Scopus ID
- 2-s2.0-85131257378
- Other Identifier
- 991021861174704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery