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What’s your diagnosis? Harlequin ichthyosis
Journal article

What’s your diagnosis? Harlequin ichthyosis

Giridhar Guntreddi, Jayasree Vasudevan Nair, Swayam Prabha Nirujogi and Family Medicine, Tower health, Reading Hospital, Reading, PA 19611, USA
Journal of Clinical Images and Medical Case Reports, v 2(2)
12 Mar 2021

Abstract

Harlequin ichthyosis is associated with high morbidity and mortality in the past. However, fetal DNA analysis, 3 D facial antenatal ultrasound, and fetal skin biopsy significantly improved the diagnostic capabilities. The current advancement in treating these babies in level 3 neonatal intensive care units with a multidisciplinary team approach and early use of oral retinoids such as Acitretin, have made the outcomes better recently. Genetic counselling and prenatal screening are of vital importance after the birth of a baby with HI. In conclusion, it is necessary for the practicing clinicians to be aware of this diagnosis and the current management protocols if they come across a similar case.

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