Patalon et al colleagues have contributed to this issue of The Journal of Pediatrics a valuable study on naturally acquired immunity to SARS-CoV-2 in children 5 to 18 years of age.1 The study was performed in Israel during a surge of coronavirus (CoV) activity and just prior to introduction of mRNA vaccines for this age group. The data show that children who had previously had PCR-positive SARS-CoV-2 infection had protection from reinfection that was substantial (ie, upwards of 80%) and durable (generally through 18 months). With the majority of children already having been infected, the authors question in children convalescing from SARS-CoV-2 both the need and timing for vaccination as well as for quarantine upon a new exposure. We are grateful for the careful study design and addition to the scarce literature on the protective effect of natural infection in children.
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When Will Strategies To Protect Children Against SARS-CoV-2 Infection Become Easier?