Journal article
Which psychotropic medications induce hepatotoxicity?
General hospital psychiatry, v 34(1), pp 53-61
Jan 2012
PMID: 22133982
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Safe prescribing practices to minimize pharmaceutically induced liver damage or worsening of preexisting conditions require knowledge about medicines with hepatotoxic potential. This paper reviews psychotropic medications and their effects on the liver.
A MEDLINE search was performed utilizing the phrase "drug-induced liver injury" with various categories of psychiatric drugs. Only articles written in English were utilized.
Hepatotoxicity can be acute or chronic in nature. Medication discontinuation is necessary in acute forms, while close monitoring is required in milder forms of medication-induced chronic liver damage. Nefazodone, pemoline and/or tacrine are the highest offenders. Carbamazepine and valproate products (e.g., divalproex) can lead to this adverse event and should be avoided in patients with liver disease, persons with alcohol misuse or those consuming high doses of acetaminophen.
Knowing the risk levels associated with various medicines is important; prescribing multiple drugs with hepatotoxic effects should be avoided. One should educate patients about early warning signs of liver injury. Always provide clinical and laboratory monitoring before and during the use of hepatotoxic drugs. Clinical features and laboratory results govern medication prescribing with ongoing risk-to-benefit ratio assessment during pharmacotherapy.
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Details
- Title
- Which psychotropic medications induce hepatotoxicity?
- Creators
- Karim Sedky - Drexel UniversityRacha Nazir - Penn State Milton S. Hershey Medical CenterAditya Joshi - Penn State Milton S. Hershey Medical CenterGagandeep Kaur - University of LouisvilleSteven Lippmann - University of Louisville
- Publication Details
- General hospital psychiatry, v 34(1), pp 53-61
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000299247800008
- Scopus ID
- 2-s2.0-84855357195
- Other Identifier
- 991019168422604721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry