Journal article
Whole Blood Resuscitation is Safe in Pediatric Trauma Patients: A Multicenter Study
The American surgeon, Vol.89(7), pp.3058-3063
01 Jul 2023
PMID: 36792959
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction Whole blood (WB) resuscitation has been associated with a mortality benefit in trauma patients. Several small series report the safe use of WB in the pediatric trauma population. We performed a subgroup analysis of the pediatric patients from a large prospective multicenter trial comparing patients receiving WB or blood component therapy (BCT) during trauma resuscitation. We hypothesized that WB resuscitation would be safe compared to BCT resuscitation in pediatric trauma patients. Methods This study included pediatric trauma patients (0-17 y), from ten level-I trauma centers, who received any blood transfusion during initial resuscitation. Patients were included in the WB group if they received at least one unit of WB during their resuscitation, and the BCT group was composed of patients receiving traditional blood product resuscitation. The primary outcome was in-hospital mortality with secondary outcomes being complications. Multivariate logistic regression was performed to assess for mortality and complications in those treated with WB vs BCT. Results Ninety patients, with both penetrating and blunt mechanisms of injury (MOI), were enrolled in the study (WB: 62 (69%), BCT: 28 (21%)). Whole blood patients were more likely to be male. There were no differences in age, MOI, shock index, or injury severity score between groups. On logistic regression, there was no difference in complications. Mortality was not different between the groups (P = .983). Conclusion Our data suggest WB resuscitation is safe when compared to BCT resuscitation in the care of critically injured pediatric trauma patients.
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Details
- Title
- Whole Blood Resuscitation is Safe in Pediatric Trauma Patients: A Multicenter Study
- Creators
- Lindsey L. Perea - Lancaster General HospitalKate Moore - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaCourtney Docherty - Reading HospitalUyen Nguyen - Penn State Milton S. Hershey Medical CenterMark J. Seamon - Hospital of the University of PennsylvaniaJames P. Byrne - Hospital of the University of PennsylvaniaDonald H. Jenkins - The University of Texas Health Science Center at San AntonioMaxwell A. Braverman - The University of Texas Health Science Center at San AntonioJohn M. Porter - Cooper University HospitalIsabella G. Armento - Cooper University HospitalCaleb Mentzer - Spartanburg Regional Healthcare SystemGuy C. Leonard - Spartanburg Regional Healthcare SystemAlejandro J. Luis - Palmetto Health RichlandMatthew R. Noorbakhsh - Allegheny General HospitalJames E. Babowice - Allegheny General HospitalHaytham M. A. Kaafarani - Massachusetts General HospitalAva Mokhtari - Massachusetts General HospitalMatthew J. Martin - Scripps Mercy HospitalJayraan Badiee - Scripps Mercy HospitalCharles Mains - Saint Anthony College of NursingRobert M. Madayag - Saint Anthony College of NursingSarah A. Moore - University of New MexicoKathleen Madden - University of New MexicoJoshua P. Hazelton - Penn State Milton S. Hershey Medical Center
- Publication Details
- The American surgeon, Vol.89(7), pp.3058-3063
- Publisher
- Sage
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000937953500001
- Scopus ID
- 2-s2.0-85148417936
- Other Identifier
- 991022056904304721
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