Journal article
Why does Finland have the highest dementia mortality rate? Environmental factors may be generalizable
Brain research, v 1671
15 Sep 2017
PMID: 28687259
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Finland has a high dementia rate related to environmental and geological factors.•Climate contributes to mold in domiciles capable of producing neurotoxic mycotoxins.•Cyanobacteria in Finnish waters contribute BMAA neurotoxins.•Presence of environmental methylmercury is a factor.•Low soil levels of selenium reduce glutathione and protection against neurotoxins.
Finland has the highest death rate from dementia in the world and its environmental features can be instructive in understanding hidden causes of dementia. Environmental factors there include: 1) a climate that is both very cold and humid resulting in housing frequently harboring molds that are capable of producing a neurotoxic mycotoxin 2) the Gulf of Finland as well as Finnish lakes harbor cyanobacteria that produce the neurotoxin, beta-N-methyl amino-L-alanine, known to cause dementia and related disorders 3) the aforementioned toxins can be potentiated by the presence of mercury and methyl mercury which can be found in Finnish waters 4) soil in Finland is naturally low in selenium and selenium deficiency may reduce the quantity and effectiveness of glutathione’s ability to protect against neurotoxins. A high rate of fatal dementia could be the consequence of these environmental factors. Studies that can support or disprove this hypothesis are suggested. Such environmental toxins are likely to promote Alzheimer’s disease elsewhere in the world where such a combination of neurotoxins may also occur.
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Details
- Title
- Why does Finland have the highest dementia mortality rate? Environmental factors may be generalizable
- Creators
- Arnold R. Eiser - Drexel University
- Publication Details
- Brain research, v 1671
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000409287200002
- Scopus ID
- 2-s2.0-85021894926
- Other Identifier
- 991019168884604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences