Windows of lead exposure sensitivity, attained height, and body mass index at 48 months

Myriam Afeiche; Karen E Peterson; Brisa N Sánchez; Lourdes Schnaas; David Cantonwine; Adrienne S Ettinger; Maritsa Solano-González; Mauricio Hernández-Avila; Howard Hu; Martha M Téllez-Rojo

doi:10.1016/j.jpeds.2011.12.022

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Windows of lead exposure sensitivity, attained height, and body mass index at 48 months

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Windows of lead exposure sensitivity, attained height, and body mass index at 48 months

Myriam Afeiche, Karen E Peterson, Brisa N Sánchez, Lourdes Schnaas, David Cantonwine, Adrienne S Ettinger, Maritsa Solano-González, Mauricio Hernández-Avila, Howard Hu and Martha M Téllez-Rojo

The Journal of pediatrics, v 160(6), pp 1044-1049

Jun 2012

DOI: https://doi.org/10.1016/j.jpeds.2011.12.022

PMID: 22284921

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

Body Mass Index

Environmental Illness - physiopathology

Follow-Up Studies

Mexico - epidemiology

Humans

Risk Factors

Child, Preschool

Infant

Male

Lead Poisoning - epidemiology

Incidence

Body Height - drug effects

Environmental Exposure - adverse effects

Lead - adverse effects

Time Factors

Environmental Illness - epidemiology

Female

Child Development - drug effects

Retrospective Studies

Infant, Newborn

Lead Poisoning - physiopathology

To examine longitudinal associations of prenatal, infancy, and early childhood lead exposure during sensitive periods with height and body mass index (BMI). A total of 773 participants were recruited between 1994 and 2005 in Mexico City. Lead exposure history categories were constructed for the prenatal period (maternal patellar lead concentration) and for infancy and childhood (mean child blood lead concentration at birth to 24 months and 30-48 months, respectively). Linear regression models were used to study lead exposure history with height and BMI at 48 months. Mean height at age 48 months was significantly lower in children with a blood lead level exceeding the median during infancy (-0.84 cm; 95% CI, -1.42 to -0.25) than in children with a level below the median. Prenatal lead exposure was not associated with height at 48 months. Results for attained BMI generally trended in the same direction as for height. Our findings suggest an effect of lead exposure early in life on height attainment at 48 months, with the exposure window of greatest sensitivity in infancy.

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29 citations in Web of Science

36 citations in Scopus

Details

Title: Windows of lead exposure sensitivity, attained height, and body mass index at 48 months
Creators: Myriam Afeiche - Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Karen E Peterson
Brisa N Sánchez
Lourdes Schnaas
David Cantonwine
Adrienne S Ettinger
Maritsa Solano-González
Mauricio Hernández-Avila
Howard Hu
Martha M Téllez-Rojo
Publication Details: The Journal of pediatrics, v 160(6), pp 1044-1049
Publisher: Elsevier; United States
Grant note: R01 ES007821 / NIEHS NIH HHS K23ES000381 / NIEHS NIH HHS K23 ES000381 / NIEHS NIH HHS R01 ES007821-11 / NIEHS NIH HHS P30 ES017885-02 / NIEHS NIH HHS R01 ES014930-05 / NIEHS NIH HHS K23 ES000381-04 / NIEHS NIH HHS K23 ES000381-01 / NIEHS NIH HHS R01 ES007821-09S1 / NIEHS NIH HHS R01 ES014930-02 / NIEHS NIH HHS P20 ES018171-03 / NIEHS NIH HHS P01 ES012874 / NIEHS NIH HHS R01 ES013744-04 / NIEHS NIH HHS P30ES017885 / NIEHS NIH HHS R01 ES014930 / NIEHS NIH HHS R01 ES007821-09 / NIEHS NIH HHS K23 ES000381-02 / NIEHS NIH HHS R01 ES007821-06A1 / NIEHS NIH HHS K23 ES000381-05 / NIEHS NIH HHS T32 ES007018 / NIEHS NIH HHS R01 ES014930-03 / NIEHS NIH HHS P20 ES018171-02 / NIEHS NIH HHS P01 ES012874-02 / NIEHS NIH HHS R01 ES013744-05 / NIEHS NIH HHS R01ES014930 / NIEHS NIH HHS R01 ES013744-02 / NIEHS NIH HHS P20 ES018171 / NIEHS NIH HHS R01 ES013744-01A2 / NIEHS NIH HHS P20 ES018171-01 / NIEHS NIH HHS T32 DK007703-16 / NIDDK NIH HHS P42 ES016454-03 / NIEHS NIH HHS R01 ES007821-08 / NIEHS NIH HHS P42 ES016454 / NIEHS NIH HHS K23 ES000381-03 / NIEHS NIH HHS P30 ES017885-01A1 / NIEHS NIH HHS R01 ES007821-10 / NIEHS NIH HHS R01 ES007821-07 / NIEHS NIH HHS P42 ES05947 / NIEHS NIH HHS R01 ES013744-06 / NIEHS NIH HHS P42 ES016454-01A2 / NIEHS NIH HHS P01 ES012874-01 / NIEHS NIH HHS P42 ES016454-02 / NIEHS NIH HHS R01 ES014930-04 / NIEHS NIH HHS R01 ES013744 / NIEHS NIH HHS R01 ES014930-01 / NIEHS NIH HHS P42 ES005947 / NIEHS NIH HHS P01 ES012874-03 / NIEHS NIH HHS R01 ES013744-03 / NIEHS NIH HHS R01ES007821 / NIEHS NIH HHS P20 ES018171/RD834800 / NIEHS NIH HHS P42 ES005947-08 / NIEHS NIH HHS T32 ES007018-31 / NIEHS NIH HHS P30 ES017885 / NIEHS NIH HHS T32 DK007703 / NIDDK NIH HHS
Resource Type: Journal article
Language: English
Academic Unit: Epidemiology and Biostatistics
Web of Science ID: WOS:000304377300031
Scopus ID: 2-s2.0-84861528152
Other Identifier: 991014878099504721

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Collaboration types: Domestic collaboration; International collaboration
Web of Science research areas: Pediatrics

Windows of lead exposure sensitivity, attained height, and body mass index at 48 months

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Abstract

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UN Sustainable Development Goals (SDGs)

InCites Highlights

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