Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Women With Psoriatic Arthritis Experience Higher Disease Burden Than Men: Findings From a Real-World Survey in the United States and Europe
Journal of rheumatology, v 50(2), pp 192-196
Feb 2023
PMID: 35970531
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although psoriatic arthritis (PsA) is equally present in men and women, sex may influence clinical manifestations and the impact of disease on patients' lives. This study assessed differences in clinical characteristics, disability, quality of life (QOL), and work productivity by sex in real-world practice.
A cross-sectional survey of rheumatologists/dermatologists and their patients with PsA was conducted in France, Germany, Italy, Spain, the United Kingdom, and the United States between June and August 2018. Data collected included demographics, treatment use, clinical characteristics (tender joint count, swollen joint count, body surface area affected by psoriasis), QOL (EuroQoL 5-Dimension questionnaire [EQ-5D], Psoriatic Arthritis Impact of Disease [PsAID12]), disability (Health Assessment Questionnaire-Disability Index [HAQ-DI]), and work productivity (Work Productivity and Impairment Index [WPAI]). Outcomes were compared between men and women using parametric and nonparametric tests, as appropriate.
Of 2270 patients (mean age 48.6 [SD 13.3] yrs, mean disease duration 4.9 [SD 6.0] yrs), 1047 (46.1%) were women. Disease duration, disease presentation, and biologic use (mean 54.2%) were comparable between women and men. Women reported worse QOL (EQ-5D: 0.80 [SD 0.2] vs 0.82 [SD 0.2];
= 0.02), greater disability (HAQ-DI: 0.56 [SD 0.6] vs 0.41 [SD 0.5];
< 0.01) and work activity impairment (WPAI: 27.9% [SD 22.0] vs 24.6% [SD 22.4];
< 0.01) than men. However, women had a lower burden of comorbidities (Charlson Comorbidity Index: 1.10 [SD 0.5] vs 1.15 [SD 0.6];
< 0.01).
In patients with similar PsA disease activity and treatment, women experienced greater disease impact than men. This represents a significant consideration for the therapeutic management of PsA.
Metrics
Details
- Title
- Women With Psoriatic Arthritis Experience Higher Disease Burden Than Men: Findings From a Real-World Survey in the United States and Europe
- Creators
- Laure Gossec - Institut Pierre Louis d‘Épidémiologie et de Santé PubliqueJessica A Walsh - University of UtahKaleb Michaud - K. Michaud, PhD, University of Nebraska Medical Center, Omaha, Nebraska, and Forward Databank, Wichita, Kansas, USASteve Peterson - S. Peterson, Janssen Global Services, LLC, Horsham, Pennsylvania, USAElizabeth A Holdsworth - Adelphi GroupChetan S Karyekar - C.S. Karyekar, PhD, Janssen Research & Development, Spring House, Pennsylvania, USANicola Booth - E.A. Holdsworth, MSc, N. Booth, MChem, Adelphi Real World, Bollington, UKSoumya D Chakravarty - Drexel University, RheumatologyAlexis Ogdie - University of Pennsylvania
- Publication Details
- Journal of rheumatology, v 50(2), pp 192-196
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Rheumatology
- Web of Science ID
- WOS:000936516300008
- Scopus ID
- 2-s2.0-85141562758
- Other Identifier
- 991021861208704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology