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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Women’s occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer
Occupational and environmental medicine (London, England), v 76(1)
Jan 2019
PMID: 30541747
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ObjectiveTo estimate the association between occupational polycyclic aromatic hydrocarbon (PAH) exposure and female breast cancer.MethodsLifetime work histories for 1130 cases and 1169 controls from British Columbia and Ontario (Canada) were assessed for PAH exposure using a job-exposure matrix based on compliance measurements obtained during US Occupational Safety and Health Administration workplace safety inspections.ResultsExposure to any level of PAHs was associated with an increased risk of breast cancer (OR=1.32, 95% CI: 1.10 to 1.59), as was duration at high PAH exposure (for >7.4 years: OR=1.45, 95% CI: 1.10 to 1.91; ptrend=0.01), compared with women who were never exposed. Increased risk of breast cancer was most strongly associated with prolonged duration at high occupational PAH exposure among women with a family history of breast cancer (for >7.4 years: OR=2.79, 95% CI: 1.25 to 6.24; ptrend<0.01).ConclusionsOur study suggests that prolonged occupational exposure to PAH may increase breast cancer risk, especially among women with a family history of breast cancer.
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Details
- Title
- Women’s occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer
- Creators
- Derrick G Lee - BC Cancer Research CentreIgor Burstyn - Drexel UniversityAgnes S Lai - BC Cancer Research CentreAnne Grundy - University of MontrealMelissa C Friesen - National Cancer InstituteKristan J Aronson - Queen's UniversityJohn J Spinelli - Population Oncology, BC Cancer, Vancouver, British Columbia, Canada.
- Publication Details
- Occupational and environmental medicine (London, England), v 76(1)
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000455200800005
- Scopus ID
- 2-s2.0-85058598389
- Other Identifier
- 991019169005104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health