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Working environment and myeloproliferative neoplasm: A population-based case-control study following a cluster investigation
Journal article   Peer reviewed

Working environment and myeloproliferative neoplasm: A population-based case-control study following a cluster investigation

Karyn Heavner, Carol Ann Gross-Davis, Arthur L Frank, Craig Newschaffer, Judith Klotz and Igor Burstyn
American journal of industrial medicine, v 58(6), pp 595-604
Jun 2015
PMID: 25880722

Abstract

Myeloproliferative Disorders - chemically induced Polycyclic Aromatic Hydrocarbons - toxicity Occupational Exposure - adverse effects Humans Middle Aged Occupations Risk Factors Transportation Hematologic Neoplasms - chemically induced Logistic Models Male Workplace Case-Control Studies Pennsylvania Industry Occupational Diseases - chemically induced Time Factors Employment Adult Female Aged Odds Ratio Cluster Analysis
Occupational exposures, including those to polycyclic aromatic hydrocarbons (PAH), are suspected risk factors for myeloproliferative neoplasms (MPN). We investigated occupational exposures and MPN risk (54 cases and 472 controls) in a population-based case-control study in three rural Pennsylvania counties. Occupational histories, coded to SIC/SOC 1980, were linked to a previously created PAH job-exposure matrix. Odds ratios for industry (17 categories), occupation (26 categories), and PAH exposure were adjusted using logistic regression. No industries or occupations were strongly or consistently associated with increased MPN risk. Analysis of employment duration found that being employed for 5 or more years in transportation, communications, and other public utilities was associated with MPN risk. There was no indication of an association with cumulative PAH exposure. These few associations did not appear to have a common exposure. This exploratory study does not support the hypothesis that occupational exposure, including PAH, are strong risk factors for MPNs.

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Collaboration types
Domestic collaboration
Web of Science research areas
Public, Environmental & Occupational Health
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