Journal article
Working environment and myeloproliferative neoplasm: A population-based case-control study following a cluster investigation
American journal of industrial medicine, Vol.58(6), pp.595-604
Jun 2015
PMID: 25880722
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Occupational exposures, including those to polycyclic aromatic hydrocarbons (PAH), are suspected risk factors for myeloproliferative neoplasms (MPN).
We investigated occupational exposures and MPN risk (54 cases and 472 controls) in a population-based case-control study in three rural Pennsylvania counties. Occupational histories, coded to SIC/SOC 1980, were linked to a previously created PAH job-exposure matrix. Odds ratios for industry (17 categories), occupation (26 categories), and PAH exposure were adjusted using logistic regression.
No industries or occupations were strongly or consistently associated with increased MPN risk. Analysis of employment duration found that being employed for 5 or more years in transportation, communications, and other public utilities was associated with MPN risk. There was no indication of an association with cumulative PAH exposure.
These few associations did not appear to have a common exposure. This exploratory study does not support the hypothesis that occupational exposure, including PAH, are strong risk factors for MPNs.
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Details
- Title
- Working environment and myeloproliferative neoplasm: A population-based case-control study following a cluster investigation
- Creators
- Karyn Heavner - Department of Environmental and Occupational Health, Drexel University, Philadelphia, PennsylvaniaCarol Ann Gross-Davis - Environmental Protection Agency, Region 3, Philadelphia, PennsylvaniaArthur L Frank - Department of Environmental and Occupational Health, Drexel University, Philadelphia, PennsylvaniaCraig Newschaffer - Drexel University, Department of Epidemiology and Biostatistics, Philadelphia, PennsylvaniaJudith Klotz - Department of Environmental and Occupational Health, Drexel University, Philadelphia, PennsylvaniaIgor Burstyn - Drexel University, Department of Epidemiology and Biostatistics, Philadelphia, Pennsylvania
- Publication Details
- American journal of industrial medicine, Vol.58(6), pp.595-604
- Publisher
- Wiley; United States
- Grant note
- 1R01EH000640-01 / NCEH CDC HHS Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Identifiers
- 991014878006504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health