Journal article
Worldwide genetic diversity of Plasmodium vivax Pv47 is consistent with natural selection by anopheline mosquitoes
Nature communications, v 16(1), pp 7363-10
09 Aug 2025
PMID: 40783499
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pv47 is the Plasmodium vivax ortholog of Pfs47, a protein that allows the Plasmodium falciparum malaria parasite to evade mosquito immunity and adapt to diverse vectors. We analyzed global genetic diversity of Pv47 and compared it with Pfs47, finding that most common Pv47 polymorphisms are non-synonymous and cluster in regions similar to those in Pfs47. Pv47 domain 2 presents an excess of non-synonymous substitutions, suggesting positive selection. The greatest haplotype diversity is found in Pv47 from East/Southeast Asia and Oceania. Like Pfs47, Pv47 also exhibits a marked geographic population structure worldwide. Notably, a Pv47 polymorphism (K27E) is associated to differences in infectivity to Anopheles (Nyssorhynchus) albimanus and Anopheles pseudopunctipennis, two phylogenetically distant vectors in Mexico. The striking similarities in genetic diversity, population structure, and signatures of natural selection between Pv47 and Pfs47 suggest that adaptation to different Anopheline mosquito species drives Pv47 diversity by selecting compatible Pv47 haplotypes.
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Details
- Title
- Worldwide genetic diversity of Plasmodium vivax Pv47 is consistent with natural selection by anopheline mosquitoes
- Creators
- Alvaro Molina-Cruz - National Institute of Allergy and Infectious DiseasesLilia Gonzalez-Ceron - Instituto Nacional de Salud PúblicaAnkit Dwivedi - University of Maryland, BaltimoreTran Zen B Torres - National Institutes of HealthNadia Raytselis - National Institutes of HealthMicah Young - National Institutes of HealthNitin Kamath - National Institutes of HealthColton McNinch - National Institutes of HealthXinzhuan Su - National Institute of Allergy and Infectious DiseasesAnthony Ford - University of North Carolina at CharlotteMarcelo U Ferreira - Universidade de São PauloMyriam Arévalo-Herrera - Caucaseco Scientific Research CenterSócrates Herrera - Caucaseco Scientific Research CenterEugenia Lo - University of North Carolina at CharlotteJoana C Silva - University of Maryland, BaltimoreCarolina Barillas-Mury - National Institute of Allergy and Infectious Diseases
- Publication Details
- Nature communications, v 16(1), pp 7363-10
- Grant note
- R01 AI162947 / NIAID NIH HHS Z01AI000947 / U.S. Department of Health & Human Services | National Institutes of Health (NIH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:001547173700011
- Scopus ID
- 2-s2.0-105012991468
- Other Identifier
- 991022192027104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Multidisciplinary Sciences