Journal article
Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
The Journal of experimental medicine, v 205(13), pp 3119-3131
22 Dec 2008
PMID: 19047440
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Correlates of immune-mediated protection to most viral and cancer vaccines are still unknown. This impedes the development of novel vaccines to incurable diseases such as HIV and cancer. In this study, we have used functional genomics and polychromatic flow cytometry to define the signature of the immune response to the yellow fever (YF) vaccine 17D (YF17D) in a cohort of 40 volunteers followed for up to 1 yr after vaccination. We show that immunization with YF17D leads to an integrated immune response that includes several effector arms of innate immunity, including complement, the inflammasome, and interferons, as well as adaptive immunity as shown by an early T cell response followed by a brisk and variable B cell response. Development of these responses is preceded, as demonstrated in three independent vaccination trials and in a novel in vitro system of primary immune responses ( modular immune in vitro construct [ MIMIC] system), by the coordinated up-regulation of transcripts for specific transcription factors, including STAT1, IRF7, and ETS2, which are upstream of the different effector arms of the immune response. These results clearly show that the immune response to a strong vaccine is preceded by coordinated induction of master transcription factors that lead to the development of a broad, polyfunctional, and persistent immune response that integrates all effector cells of the immune system.
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Details
- Title
- Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
- Creators
- Denis Gaucher - Centre Hospitalier de l’Université de MontréalRene Therrien - Centre Hospitalier de l’Université de MontréalNadia Kettaf - Centre Hospitalier de l’Université de MontréalBastian R. Angermann - Centre Hospitalier de l’Université de MontréalGenevieve Boucher - Centre Hospitalier de l’Université de MontréalAbdelali Filali-Mouhim - Centre Hospitalier de l’Université de MontréalJanice M. Moser - VerisignRiyaz S. Mehta - VerisignDonald R. Drake - VerisignErika Castro - University Hospital of LausanneRama Akondy - Emory UniversityAline Rinfret - Health CanadaBader Yassine-Diab - Centre Hospitalier de l’Université de MontréalElias A. Said - Centre Hospitalier de l’Université de MontréalYounes Chouikh - Centre Hospitalier de l’Université de MontréalMark J. Cameron - University Health NetworkRobert Clum - University Health NetworkDavid Kelvin - University Health NetworkRoland Somogyi - Biosystemix, Ltd., Sydenham, Ontario K0H 2T0, CanadaLarry D. Greller - Biosystemix, Ltd., Sydenham, Ontario K0H 2T0, CanadaRobert S. Balderas - BD Biosciences (United States)Peter Wilkinson - Centre Hospitalier de l’Université de MontréalGiuseppe Pantaleo - University Hospital of LausanneJim Tartaglia - Sanofi PasteurElias K. Haddad - McGill UniversityRafick-Pierre Sekaly - Centre Hospitalier de l’Université de Montréal
- Publication Details
- The Journal of experimental medicine, v 205(13), pp 3119-3131
- Publisher
- Rockefeller Univ Press
- Number of pages
- 13
- Grant note
- Fonds de la recherche en sante du Quebec; Fonds de la Recherche en Sante du Quebec IAVI Innovation Fund INSERM; Institut National de la Sante et de la Recherche Medicale (Inserm); European Commission Institut National de la Sante et de la Recherche Medicale (INSERM); Institut National de la Sante et de la Recherche Medicale (Inserm) Canadian Network for Vaccines and Immunotherapeutics (CANVAC) Genome Canada, Genome Quebec; Genome Canada
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000266428700017
- Scopus ID
- 2-s2.0-59649129816
- Other Identifier
- 991020099299804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental