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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC)
Cancer epidemiology, biomarkers & prevention, v 26(6), pp 876-885
Jun 2017
PMID: 28223430
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI.
We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls.
In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m
increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04-1.14;
= 0.007]. We observed significant heterogeneity by study design (
= 0.04), noting the BMI-multiple myeloma association only for population-based studies (
= 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m
; OR, 1.2; 95% CI, 1.1-1.3;
= 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (
<0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25-<30 kg/m
) or obese (30+ kg/m
) in both younger and usual adulthood (vs. individuals consistently <25 kg/m
), but not for those overweight or obese at only one time period.
BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood.
These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention.
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Details
- Title
- Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC)
- Creators
- Brenda M Birmann - Brigham and Women's HospitalGabriella Andreotti - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.Anneclaire J De Roos - Drexel UniversityNicola J Camp - University of UtahBrian C H Chiu - University of ChicagoJohn J Spinelli - BC Cancer AgencyNikolaus Becker - German Cancer Research CenterVéronique Benhaim-Luzon - International Agency For Research On CancerParveen Bhatti - University of WashingtonPaolo Boffetta - Icahn School of Medicine at Mount SinaiPaul Brennan - International Agency For Research On CancerElizabeth E Brown - University of Alabama at BirminghamPierluigi Cocco - University of CagliariLaura Costas - Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain.Wendy Cozen - University of Southern CaliforniaSilvia de Sanjosé - Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain.Lenka Foretová - Masaryk Memorial Cancer InstituteGraham G Giles - Cancer Council VictoriaMarc Maynadié - University of BurgundyKirsten Moysich - Roswell Park Cancer InstituteAlexandra Nieters - University of FreiburgAnthony Staines - Dublin City UniversityGuido Tricot - University of IowaDennis Weisenburger - City Of Hope National Medical CenterYawei Zhang - Yale UniversityDalsu Baris - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.Mark P Purdue - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland.
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 26(6), pp 876-885
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- R13 CA159842 / NCI NIH HHS R01 CA149445 / NCI NIH HHS P30 CA042014 / NCI NIH HHS R21 CA198239 / NCI NIH HHS R01 CA127435 / NCI NIH HHS P30 CA014089 / NCI NIH HHS P30 CA086862 / NCI NIH HHS K07 CA115687 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000402765600009
- Scopus ID
- 2-s2.0-85020232130
- Other Identifier
- 991019168477504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health