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Journal article
Youth with Down syndrome display widespread increased functional connectivity during rest
Scientific reports, v 12(1), pp 9836-9836
14 Jun 2022
PMID: 35701489
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Studies of resting-state functional connectivity in young people with Down syndrome (DS) have yielded conflicting results. Some studies have found increased connectivity while others have found a mix of increased and decreased connectivity. No studies have examined whole-brain connectivity at the voxel level in youth with DS during an eyes-open resting-state design. Additionally, no studies have examined the relationship between connectivity and network selectivity in youth with DS. Thus, the current study sought to fill this gap in the literature. Nineteen youth with DS (M
= 16.5; range 7-23; 13 F) and 33 typically developing (TD) youth (M
= 17.5; range 6-24; 18 F), matched on age and sex, completed a 5.25-min eyes-open resting-state fMRI scan. Whole-brain functional connectivity (average Pearson correlation of each voxel with every other voxel) was calculated for each individual and compared between groups. Network selectivity was then calculated and correlated with functional connectivity for the DS group. Results revealed that whole-brain functional connectivity was significantly higher in youth with DS compared to TD controls in widespread regions throughout the brain. Additionally, participants with DS had significantly reduced network selectivity compared to TD peers, and selectivity was significantly related to connectivity in all participants. Exploratory behavioral analyses revealed that regions showing increased connectivity in DS predicted Verbal IQ, suggesting differences in connectivity may be related to verbal abilities. These results indicate that network organization is disrupted in youth with DS such that disparate networks are overly connected and less selective, suggesting a potential target for clinical interventions.
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Details
- Title
- Youth with Down syndrome display widespread increased functional connectivity during rest
- Creators
- Kelsey D Csumitta - Drexel UniversityStephen J Gotts - Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USALiv S Clasen - Section on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USAAlex Martin - Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USANancy Raitano Lee - Department of Psychological and Brain Sciences, Drexel University, Philadelphia, PA, 19103, USA. nrl39@drexel.edu
- Publication Details
- Scientific reports, v 12(1), pp 9836-9836
- Publisher
- Springer Nature
- Grant note
- 1646737 / National Science Foundation Graduate Research Fellowship R21HD100997 / Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000811293500008
- Scopus ID
- 2-s2.0-85132050331
- Other Identifier
- 991019168093004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences