Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome

Zachary A Klase; Svetlana Khakhina; Adriano De Bernardi Schneider; Michael V Callahan; Jill Glasspool-Malone; Robert Malone

doi:10.1371/journal.pntd.0004877

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Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome

Journal article

Open access

Peer reviewed

Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome

Zachary A Klase, Svetlana Khakhina, Adriano De Bernardi Schneider, Michael V Callahan, Jill Glasspool-Malone and Robert Malone

PLoS neglected tropical diseases, v 10(8), e0004877

25 Aug 2016

DOI: https://doi.org/10.1371/journal.pntd.0004877

PMID: 27560129

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Abstract

Adult

Americas - epidemiology

Brain - pathology

Brain - virology

Disease Outbreaks

Epidemics

Fetal Diseases - pathology

Fetal Diseases - virology

Fetus - virology

Flavivirus Infections - epidemiology

Flavivirus Infections - virology

Genome, Viral

Guillain-Barre Syndrome - epidemiology

Guillain-Barre Syndrome - virology

Humans

Microcephaly - economics

Microcephaly - virology

Virus Replication

Zika Virus - genetics

Zika Virus - pathogenicity

Zika Virus - physiology

Zika Virus Infection - complications

Zika Virus Infection - physiopathology

Zika Virus Infection - virology

The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain-Barré syndrome) has brought attention to this neglected pathogen. While initial case studies generated significant interest in the Zika virus outbreak, larger prospective epidemiology and basic virology studies examining the mechanisms of Zika viral infection and associated pathophysiology are only now starting to be published. In this review, we analyze Zika fetal neuropathogenesis from a comparative pathology perspective, using the historic metaphor of "TORCH" viral pathogenesis to provide context. By drawing parallels to other viral infections of the fetus, we identify common themes and mechanisms that may illuminate the observed pathology. The existing data on the susceptibility of various cells to both Zika and other flavivirus infections are summarized. Finally, we highlight relevant aspects of the known molecular mechanisms of flavivirus replication.

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Title: Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome
Creators: Zachary A Klase - University of the Sciences
Svetlana Khakhina - University of the Sciences
Adriano De Bernardi Schneider - University of North Carolina at Charlotte
Michael V Callahan - Massachusetts General Hospital
Jill Glasspool-Malone - Harvard University
Robert Malone - Harvard University
Publication Details: PLoS neglected tropical diseases, v 10(8), e0004877
Publisher: Public LIbrary of Science (PLOS)
Resource Type: Journal article
Language: English
Academic Unit: Pharmacology and Physiology
Web of Science ID: WOS:000382390800024
Scopus ID: 2-s2.0-84988719545
Other Identifier: 991021902599904721

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Collaboration types: Domestic collaboration
Web of Science research areas: Infectious Diseases; Parasitology; Tropical Medicine

Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome

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Abstract

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UN Sustainable Development Goals (SDGs)

InCites Highlights

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