Journal article
Zona Incerta GABAergic Output Controls a Signaled Locomotor Action in the Midbrain Tegmentum
ENEURO, v 7(1), 0390-19.2020
Jan 2020
PMID: 32041743
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The zona incerta is a subthalamic nucleus proposed to link sensory stimuli with motor responses to guide behavior, but its functional role is not well established. Using mice of either sex, we studied the effect of manipulating zona incerta GABAergic cells on the expression of a signaled locomotor action, known as signaled active avoidance. We found that modulation of GABAergic zona incerta cells, but not of cells in the adjacent thalamic reticular nucleus (NRT), fully controls the expression of signaled active avoidance responses. Inhibition of zona incerta GABAergic cells drives active avoidance responses, while excitation of these cells blocks signaled active avoidance mainly by inhibiting cells in the midbrain pedunculopontine tegmental nucleus (PPT). The zona incerta regulates signaled locomotion in the midbrain.
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Details
- Title
- Zona Incerta GABAergic Output Controls a Signaled Locomotor Action in the Midbrain Tegmentum
- Publication Details
- ENEURO, v 7(1), 0390-19.2020
- Publisher
- SOC NEUROSCIENCE; WASHINGTON
- Grant note
- This work was supported by the Department of Health and Human Services National Institutes of Health National Institute of Neurological Disorders and Stroke.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000562401500027
- Scopus ID
- 2-s2.0-85079863408
- Other Identifier
- 991021860775604721
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- Web of Science research areas
- Neurosciences