Journal article
( d)-2- tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagogues
Bioorganic & medicinal chemistry letters, v 18(14), pp 4072-4074
15 Jul 2008
PMID: 18554903
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The first enantioselective synthesis of (
d)-2-
tert-butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid
3 was achieved. The incorporation of the titled compound into growth hormone secretagogue (GHS) compounds resulted in new analogs
10 and
16, both of which had significantly increased in vitro potency. The compound
10 also showed improved in vivo efficacy as well as pharmacokinetic properties in rat models.
Metrics
Details
- Title
- ( d)-2- tert-Butoxycarbonylamino-5,5-difluoro-5-phenyl-pentanoic acid: Synthesis and incorporation into the growth hormone secretagogues
- Creators
- Jun Li - Bristol-Myers Squibb (United States)Stephanie Y. Chen - Bristol-Myers Squibb (United States)Brian J. Murphy - Bristol-Myers Squibb (United States)Neil Flynn - Bristol-Myers Squibb (United States)Ramakrishna Seethala - Bristol-Myers Squibb (United States)Dorothy Slusarchyk - Bristol-Myers Squibb (United States)Mujing Yan - Bristol-Myers Squibb (United States)Paul Sleph - Bristol-Myers Squibb (United States)Hongjian Zhang - Bristol-Myers Squibb (United States)William G. Humphreys - Bristol-Myers Squibb (United States)William R. Ewing - Bristol-Myers Squibb (United States)Jeffrey A. Robl - Bristol-Myers Squibb (United States)David Gordon - Bristol-Myers Squibb (United States)Joseph A. Tino - Bristol-Myers Squibb (Germany)
- Publication Details
- Bioorganic & medicinal chemistry letters, v 18(14), pp 4072-4074
- Publisher
- Elsevier
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000257640400055
- Scopus ID
- 2-s2.0-47349115764
- Other Identifier
- 991021902517504721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic