Journal article
for all the participants. Atherogenic risk indices I&II, Atherogenic coefficient Atherogenic Index of Plasma (AIP) were calcu- formulas. A comparison between the study by using the Independent t-test and
Journal of medical biochemistry, v 42(1), pp 58-66
01 Jan 2023
PMID: 36819139
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background:Hypothyroidism can predispose systolic anddiastolic cardiac dysfunction, increased peripheral vascularresistance, endothelial dysfunction, altered coagulopathy,and dyslipidemia resulting in atherosclerosis. Thyroid hor-mones can influence homocysteine metabolism by regulat-ing the methylenetetrahydrofolate reductase (MTHR). So,this study aimed to compare the markers homocysteine,high sensitive C-reactive protein (hs-CRP), and Athero-genic Indices (AI) between newly diagnosed hypothyroidand euthyroid premenopausal women.Methods:80 Female patients between 20 and 45 yearswere enrolled in this study and were equally divided intocases and controls group. Laboratory tests included: i)Serum T3, T4, TSH was measured using electrochemilu-minescence, ii) lipid profile, homocysteine, and hs-CRPwere measured for all the participants. Atherogenicindices: Castelli risk indices I&II, Atherogenic coefficient(AEC), and Atherogenic Index of Plasma (AIP) were calcu-lated using formulas. A comparison between the studygroups was made by using the Independent t-test andMann-Whitney U test. p-value <0.05 was considered sig-nificant.Results:The hypothyroid group had significantly higher levels of homocysteine (p=0.014), and hs-CRP (hs-CRP >3.0 mg/L, 70% of participants have intermediate to highrisk for a cardiovascular event) and elevated BMI comparedto participants in the euthyroid group. Atherogenic indices(p<0.001) was significantly increased in the hypothyroidparticipants' group. TC, TG, and LDL were significantly ele-vated in the hypothyroid group but did not show any asso-ciation with systolic and diastolic blood pressure.Conclusions:Premenopausal women with hypothyroidismhave a greater predisposition for cardiovascular diseasecompared to euthyroid
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Details
- Title
- for all the participants. Atherogenic risk indices I&II, Atherogenic coefficient Atherogenic Index of Plasma (AIP) were calcu- formulas. A comparison between the study by using the Independent t-test and
- Creators
- Vaideki Balamurugan - Circle (United States)Ravindra Maradi - Circle (United States)Vivek Joshi - Drexel Univ, Reading, PA 19610 USAVijetha Shenoy Belle - Circle (United States)Manjunatha B. K. Goud - College Station Medical Center
- Publication Details
- Journal of medical biochemistry, v 42(1), pp 58-66
- Publisher
- SOC MEDICAL BIOCHEMISTS SERBIA
- Number of pages
- 9
- Grant note
- Manipal Academy of Higher Education, India Kasturba Medical College
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000954022300007
- Scopus ID
- 2-s2.0-85149661599
- Other Identifier
- 991021229989204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology