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Journal article
miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
Cell Stress, v 2(2), pp 34-36
01 Feb 2018
PMID: 31225464
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants with lifelong pulmonary and neurodevelopmental consequences. The pathogenesis of BPD is contributed by genetic and environmental factors; among the latter, a critical contributor is exposure of the developing lung to hyperoxia. We have recently reported (Nat Comm 8:1173) that hyperoxia exposure in our in vitro and in vivo modeling systems of hyperoxia-induced lung injury (HALT) and BPD leads to an upregulation of the microRNA (miR) 34a. Utilizing genetic loss- and gain- of function strategies, we show that miR34a inhibition ameliorates the pulmonary phenotype of BPD (including BPD-associated pulmonary hypertension), at least in part, via one of the downstream targets of miR34a, namely Angiopoietin1/Tie 2 signaling. In addition, we demonstrate translational clinical significance of our findings by showing increased miR34a and decreased Ang1 expression in 3 independent cohorts of human lung samples.
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Details
- Title
- miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
- Creators
- Pragnya Das - Drexel Univ, Coll Med, Dept Pediat, Sect Neonatol, Philadelphia, PA 19102 USAMansoor Ali Syed - Drexel Univ, Coll Med, Dept Pediat, Sect Neonatol, Philadelphia, PA 19102 USADilip Shah - Drexel Univ, Coll Med, Dept Pediat, Sect Neonatol, Philadelphia, PA 19102 USAVineet Bhandari - Drexel Univ, Coll Med, Dept Pediat, Sect Neonatol, Philadelphia, PA 19102 USA
- Publication Details
- Cell Stress, v 2(2), pp 34-36
- Publisher
- Shared Science Publishers Og
- Number of pages
- 3
- Grant note
- Hartwell Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000588295400003
- Scopus ID
- 2-s2.0-85088482473
- Other Identifier
- 991019167453504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology