Journal article
miRNA packaging into small extracellular vesicles and implications in pain
Pain reports, v 9(6), e1198
Dec 2024
PMID: 39450410
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Small extracellular vesicles are an emerging pain therapeutic that are nonimmunogenic and biodegradable. We discuss how these naturally occurring nanocarriers package miRNAs as cargo.
Extracellular vesicles (EVs) are a heterogenous group of lipid bilayer bound particles naturally released by cells. These vesicles are classified based on their biogenesis pathway and diameter. The overlap in size of exosomes generated from the exosomal pathway and macrovesicles that are pinched off from the surface of the plasma membrane makes it challenging to isolate pure populations. Hence, isolated vesicles that are less than 200 nm are called small extracellular vesicles (sEVs). Extracellular vesicles transport a variety of cargo molecules, and multiple mechanisms govern the packaging of cargo into sEVs. Here, we discuss the current understanding of how miRNAs are targeted into sEVs, including the role of RNA binding proteins and EXOmotif sequences present in miRNAs in sEV loading. Several studies in human pain disorders and rodent models of pain have reported alterations in sEV cargo, including miRNAs. The sorting mechanisms and target regulation of miR-939, a miRNA altered in individuals with complex regional pain syndrome, is discussed in the context of inflammation. We also provide a broad overview of the therapeutic strategies being pursued to utilize sEVs in the clinic and the work needed to further our understanding of EVs to successfully deploy sEVs as a pain therapeutic.
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Details
- Title
- miRNA packaging into small extracellular vesicles and implications in pain
- Creators
- Jason T. DaCunza - Drexel UniversityJason R. Wickman - Drexel UniversitySeena K. Ajit - Drexel University
- Publication Details
- Pain reports, v 9(6), e1198
- Publisher
- Wolters Kluwer
- Number of pages
- 15
- Grant note
- R01NS129191 / National Institute of Neurological Disorders and Stroke RF1NS130481 / National Institute of Neurological Disorders and Stroke
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001368255000007
- Scopus ID
- 2-s2.0-85208546815
- Other Identifier
- 991021932215304721
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- Web of Science research areas
- Neurosciences