Journal article
para-Aminobenzoate Synthesis versus Salvage in Malaria Parasites
Trends in parasitology, v 35(3)
01 Mar 2019
PMID: 30709568
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Enzymes of the folate de novo synthesis pathway in malaria parasites are proven antimalarial drug targets. A key precursor for folate synthesis is para-aminobenzoate (pABA). In a recent study [1] (Cell Rep. 2019; 26: 356-363 e4), the contributions of pABA synthesis versus salvage were re-evaluated in a rodent malaria model with knockout parasites grown in mice fed with various diets. The results imply that malaria parasites can either synthesize or salvage pABA to meet the demand for folates.
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Details
- Title
- para-Aminobenzoate Synthesis versus Salvage in Malaria Parasites
- Creators
- Michael W. Mather - Drexel UniversityHangjun Ke - Drexel University
- Publication Details
- Trends in parasitology, v 35(3)
- Publisher
- Elsevier
- Number of pages
- 4
- Grant note
- K22 AI127702 / NIAID NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000459168500002
- Scopus ID
- 2-s2.0-85060621633
- Other Identifier
- 991019168544404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Parasitology