Logo image
Back
Association of Nasal and Inhalant Corticosteroids With Pediatric Perioral Dermatitis: A TriNetX Retrospective Cohort Study
Letter/Communication   Open access   Peer reviewed

Association of Nasal and Inhalant Corticosteroids With Pediatric Perioral Dermatitis: A TriNetX Retrospective Cohort Study

Taylor Merkle, Caitlyn Curley, Dylan Wambold, Basira Iginla and Erum N Ilyas
Pediatric dermatology, Forthcoming
10 May 2026
DOI: https://doi.org/10.1111/pde.70228
PMID: 42107964
Featured in Collection :   Drexel's Newest Publications
url
https://doi.org/10.1111/pde.70228View
Published, Version of Record (VoR) Open Access via Drexel Libraries Read and Publish Program 2026 Open CC BY-NC-ND V4.0

Abstract

corticosteroid intranasal sprays allergic rhinitis corticosteroid inhalants perioral dermatitis Asthma
Although topical corticosteroids are known triggers in the development of perioral dermatitis (PD), investigation into inhalant and nasal corticosteroid preparations, commonly used to manage allergic rhinitis and asthma, remains limited to case series. Using the TriNetX US Collaborative Network, this retrospective cohort study identified pediatric patients (age < 18) with allergic rhinitis or asthma in three groups: corticosteroid nasal/inhalant users, non-steroid nasal/inhalant users, and controls with no nasal/inhalant product use. Patients were propensity score matched 1:1 from 2000 to 2025 with a new diagnosis of PD as the outcome assessed at 6 and 12 months. Corticosteroid nasal/inhalant usage showed an increased association of newly documented PD with the strongest signal occurring within 6 months (RR 3.25, p < 0.0001) remaining persistently elevated although attenuated by 1 year (RR 2.27, p < 0.0001), whereas nonsteroidal preparations showed no such association. Nasal and inhalant containing corticosteroid preparations were clearly associated with PD in this large retrospective database study. They represent a likely underrepresented trigger necessitating clinician attention when encountering new-onset pediatric facial dermatoses.

Metrics

1 Record Views

Details

Logo image