Letter/Communication
Lamina cribrosa shape in non-human primates is different from that of humans
Experimental eye research, v 261, 110696
01 Dec 2025
PMID: 41109592
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Non-human primates (NHPs) are a crucial model for studying glaucoma because of their similarities to humans in anatomy, physiology and pathology. Our goal in this study was to quantify in vivo NHP lamina cribrosa (LC) shapes at low, normal, and elevated intraocular pressures (IOPs), and compare them with literature reported values for in vivo human LCs. We imaged the optic nerve heads (ONH) of seven eyes from six rhesus macaque monkeys using spectral-domain optical coherence tomography (SD-OCT) at several IOP levels while keeping intracranial pressure at baseline. LC shape was characterized by measuring shape index (SI) and curvedness from manually delineated marks of the anterior LC surface. We found that LC shape in NHPs was more similar across individuals at normal IOP than it is in humans. This was, in part, because the NHPs LCs did not exhibit the characteristic horizontal central ridge seen in human LCs and were instead less saddle-shaped and more trough-shaped. With increasing IOP, NHPs LCs curvedness increased, without significant changes in SI, differing from the human response where SI decreases. These findings emphasize the importance of characterizing species-specific differences in anatomy and biomechanics, and the need to determine how these differences may impact susceptibility to glaucomatous damage.
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Details
- Title
- Lamina cribrosa shape in non-human primates is different from that of humans
- Creators
- Miriam Bohlmann Kunz - University of PittsburghZiyi Zhu - University of PittsburghSusannah Waxman - University of PittsburghBo Wang - Johns Hopkins UniversityJacob Wallace - University of PittsburghSamantha E. Schmitt - Carnegie Mellon UniversityHiroshi Ishikawa - Oregon Health & Science UniversityJoel S. Schuman - Wills Eye HospitalMatthew A. Smith - Carnegie Mellon UniversityGadi Wollstein - Wills Eye HospitalIan A. Sigal - University of Pittsburgh
- Publication Details
- Experimental eye research, v 261, 110696
- Publisher
- Elsevier
- Resource Type
- Letter/Communication
- Language
- English
- Academic Unit
- School of Biomedical Engineering and Science
- Web of Science ID
- WOS:001607341700009
- Scopus ID
- 2-s2.0-105019092902
- Other Identifier
- 991022197328104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology