Letter/Communication
Long-term aspirin desensitization has mucosal cytokine features of immune tolerance
Allergy (Copenhagen), v 79(2), pp 507-509
Feb 2024
PMID: 37727998
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aspirin (ASA)-exacerbated respiratory disease (AERD) is a complex upper and lower airway inflammatory disorder characterized by hypersensitivity to cyclooxygenase (COX) inhibitors, chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma.1 Aspirin desensitization is one treatment option, but the therapeutic mechanisms underlying its efficacy are complex. While aspirin desensitization is achieved in a 1- to 2- day protocol, the clinical benefits of desensitization take 6-12 months to fully manifest2 with little known about the inflammatory changes induced by long-term aspirin desensitization. This study aimed to characterize the long-term inflammatory shifts in sinus mucosa post-aspirin desensitization. [1st paragraph]
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Details
- Title
- Long-term aspirin desensitization has mucosal cytokine features of immune tolerance
- Creators
- Michael A Kohanski - Department of Otorhinolaryngology-Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USAAnas Qatanani - Drexel UniversityCailu Lin - Monell Chemical Senses CenterLi Hui Tan - University of PennsylvaniaJeremy Chang - University of PennsylvaniaAndrew Corr - University of PennsylvaniaSabrina Herzberg - University of PennsylvaniaNithin D Adappa - Department of Otorhinolaryngology-Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USAJames N Palmer - Department of Otorhinolaryngology-Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USADanielle R Reed - Monell Chemical Senses CenterJohn V Bosso - University of PennsylvaniaNoam A Cohen - Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
- Publication Details
- Allergy (Copenhagen), v 79(2), pp 507-509
- Publisher
- Wiley
- Number of pages
- 3
- Grant note
- University of Pennsylvania American Rhinologic Society
- Resource Type
- Letter/Communication
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001068817600001
- Scopus ID
- 2-s2.0-85171589343
- Other Identifier
- 991021861299604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Allergy
- Immunology