Cardiovascular Diseases Secondary Prevention Vulnerable Populations Humans Drug Combinations
Muñoz and colleagues found that the polypill can reduce cardiovascular risk among vulnerable persons at intermediate-to-high risk. Despite the promising findings,1 polypill approaches to primary prevention in low-income populations address the tip of a much larger iceberg, particularly if used regardless of baseline risk.1,2 Fundamental causes of disease,3 such as disadvantageous socioeconomic conditions, are at the root of a variety of adverse health outcomes, including cardiovascular disease and cancer, both of which disproportionately affect the poor. Fundamental causes operate through pathways that include unhealthy diets, sedentary behaviors, smoking, excessive alcohol consumption, and psychosocial stress.3 Interventions that ignore fundamental causes and focus on proximal factors let the former affect health through other mechanisms. Lack of structural interventions may explain the decline in life expectancy observed in the United States in recent years despite an 80% increase in statin use.4 We applaud efforts to improve therapeutic adherence and the management of cardiovascular risk among high-risk persons from underserved communities using polypills. However, before escalating these to larger populations with heterogeneous risks,1,2 we should work to invent a polypill against social injustice and poverty.
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Details
Title
Polypill for Cardiovascular Disease Prevention in an Underserved Population
Creators
Usama Bilal - Drexel University
Miguel Cainzos-Achirica - Johns Hopkins University
Publication Details
The New England journal of medicine, v 382(1), pp 94-95
Publisher
New England Journal of Medicine; United States
Number of pages
2
Resource Type
Letter/Communication
Language
English
Academic Unit
Urban Health Collaborative
Web of Science ID
WOS:000505606700026
Scopus ID
2-s2.0-85077208266
Other Identifier
991014878183404721
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