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Reply [Bonney EA, Matzinger P. The maternal immune system’s interaction with circulating fetal cells. J Immunol 1997; 158:40–7]
Letter/Communication   Open access

Reply [Bonney EA, Matzinger P. The maternal immune system’s interaction with circulating fetal cells. J Immunol 1997; 158:40–7]

Paul J. Christner and Carol M. Artlett
Arthritis and rheumatism, v 44(12), pp 2945-2945
Dec 2001
DOI: https://doi.org/10.1002/1529-0131(200112)44:12<2945::AID-ART495>3.0.CO;2-H
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https://doi.org/10.1002/1529-0131(200112)44:12<2945::aid-art495>3.0.co;2-hView
Published, Version of Record (VoR)Open Access (Publisher-Specific),  Open

Abstract

Bonney and Matzinger investigated for fetal cells in the peripheral blood and organs of mice that had been bred 2–3 times (Bonney EA, Matzinger P. The maternal immune system’s interaction with circulating fetal cells. J Immunol 1997; 158:40–7). They reported the presence of microchimerism in 35% of the females that had had pregnancies. Peripheral blood contained the highest number of microchimeric cells. They also reported that the mice were able to clear essentially all the microchimeric cells by 8 weeks post-delivery. They concluded that in the murine system microchimerism occurs in a minority of pregnant mothers and that detectable fetal cells could be eliminated in all animals after 8 weeks. [1st paragraph]

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Rheumatology
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