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Letter/Communication
Reversible neuroinhibition does not require a thermal mechanism
Brain stimulation, v 13(1), pp 262-262
01 Jan 2020
PMID: 31582302
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We wish to respond to the recent publication by Darrow et al. titled “Reversible Neuroinhibition by Focused Ultrasound is mediated by a Thermal Mechanism [1].” Specifically, we wish to alert the larger transcranial Focused Ultrasound Sonication (tFUS) community regarding inducing reversible neuroinhibition without thermal changes. Prior research has clearly demonstrated neuroinhibition without the temperature change suggested by Darrow et al. In a study attempting to suppress regional cortical excitability in rabbits, fMRI BOLD was used to monitor neural activity in the visual cortex after LED light stimulation [2]. Focused Ultrasound with a tone burst duration of 0.5 msec, Pulse repetition frequency = 100 Hz, and Isppa = 3.3 W/cm2 successfully suppressed the BOLD signal caused by light stimulation. The authors initially set out to confirm the accuracy of their targeting in rabbits using MR thermometry [3]. [first paragraph]
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Details
- Title
- Reversible neuroinhibition does not require a thermal mechanism
- Creators
- Norman M. Spivak - University of California Los AngelesMark E. Schafer - Sonic Tech, Inc (United States, Lower Gwynedd)Alexander Bystritsky - University of California Los Angeles
- Publication Details
- Brain stimulation, v 13(1), pp 262-262
- Publisher
- Elsevier
- Number of pages
- 1
- Resource Type
- Letter/Communication
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000499654900033
- Scopus ID
- 2-s2.0-85075571107
- Other Identifier
- 991019176798804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences