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Tissue is the issue in transient ischemic attack and stroke
Letter/Communication   Open access   Peer reviewed

Tissue is the issue in transient ischemic attack and stroke

Lewis B Morgenstern and Brisa N Sánchez
Annals of neurology, v 75(2), pp 171-172
Feb 2014
DOI: https://doi.org/10.1002/ana.24082
PMID: 24318353
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://deepblue.lib.umich.edu/bitstream/2027.42/106671/1/ana24082.pdfView
SubmittedOpen Access (License Unspecified),  Open

Abstract

Most of us were taught in medical school that a transient ischemic attack (TIA) was a stroke syndrome that resolved within 24 hours. With the advent of diffusion-weighted magnetic resonance imaging (DW-MRI), several observers noted that although clinical symptoms had resolved in TIA patients, some had positive DW-MRI signal, implying infarcted brain. Because the overwhelming majority of TIAs resolve within 1hour, and so many patients with symptoms lasting longer than several minutes have positive DW-MRI signal, anew definition of TIA was proposed a decade ago, which included brief focal neurologic symptoms referable to avascular territory that did not have imaging signal implying infarction. Conversely, a new “tissue” definition of stroke, to distinguish it from TIA, has emerged to encompass clinical symptoms lasting >24 hours and/or evidence of infarcted brain at any time point, most frequently observed by DW-MRI. [1st paragraph]

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Web of Science research areas
Clinical Neurology
Neurosciences
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