Letter/Communication
Use of dupilumab in patients who are HIV-positive: report of four cases
British Journal of Dermatology, v 181(6), pp 1311-1312
01 Dec 2019
PMID: 31206599
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Atopic dermatitis (AD) and prurigo nodularis (PN) are defined by the drive to itch. Indeed, AD is so intensely pruritic, it is described as the itch that rashes. Incidences of AD and PN are higher in patients with HIV, with a prevalence of 30–50% in patients who are HIV‐positive, in contrast to a prevalence of 2–5% in seronegative adults.1 Additionally, approximately 39% of patients with HIV have PN, supporting PN as the most frequent skin disorder in patients who are HIV‐positive.1
Dupilumab, a novel monoclonal interleukin (IL)‐4/IL‐13 antagonist, is the first biologic approved for the treatment of moderate‐to‐severe AD. Recent reports have described that dupilumab provides improvement in patients with PN.2 Unfortunately, the effects of dupilumab in patients who are HIV‐positive are unknown, as these patients were excluded from clinical trials. Herein, we describe four patients with HIV, two with concomitant AD and two with concomitant PN, that were treated safely and successfully with dupilumab. All patients reported an improvement in the severity of itch as measured by the numerical rating scale for itch intensity (NRSi). Clinical improvement was noted for all patients as measured by the Investigator's Global Assessment (IGA). NRSi, IGA and HIV laboratory values are summarized in Table 1.
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Details
- Title
- Use of dupilumab in patients who are HIV-positive: report of four cases
- Creators
- N. K. Mollanazar (Corresponding Author) - Temple UniversityC. C. Qiu - Temple UniversityJ. L. Aldrich - Temple UniversityE. Tedaldi - Temple UniversityR. Valdes- Rodriguez - Temple UniversityK. T. Savage - Drexel UniversityS. Hsu - Temple University
- Publication Details
- British Journal of Dermatology, v 181(6), pp 1311-1312
- Number of pages
- 2
- Resource Type
- Letter/Communication
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000489267800001
- Scopus ID
- 2-s2.0-85074011515
- Other Identifier
- 991021860811204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology