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Hemostasis biomarkers and incident cognitive impairment: the REGARDS study
Journal of thrombosis and haemostasis, v 16(7), pp 1259-1267
06 Jun 2018
PMID: 29733497
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Vascular risk factors are associated with cognitive impairment, a condition with substantial public health burden. We hypothesized that hemostasis biomarkers related to vascular disease would be associated with risk of incident cognitive impairment. METHODS: We performed a nested case control study including 1,082 participants with 3.5 years of follow-up in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a longitudinal cohort study of 30,239 black and white Americans ≥45 years old. Participants were free of stroke or cognitive impairment at baseline. Baseline D-dimer, fibrinogen, factor VIII, and protein C were measured in 495 cases who developed cognitive impairment during follow-up (based on abnormal scores on ≥2 of 3 cognitive tests) and 587 controls. RESULTS: Unadjusted ORs for incident cognitive impairment were 1.32 (95% CI 1.02, 1.70) for D-dimer >0.50 μg/mL, 1.83 (CI 1.24, 2.71) for fibrinogen >90(th) percentile, 1.63 (CI 1.11, 2.38) for factor VIII >90(th) percentile and 1.10 (CI 0.73, 1.65) for protein C < 10(th) percentile. There were no differences in associations by race or region. Adjustment for demographic, vascular and health behavior risk factors attenuated these associations. However, having at least 2 elevated biomarkers was associated with incident cognitive impairment, with an adjusted OR 1.73 (CI 1.10, 2.69). CONCLUSION: Elevated D-dimer, fibrinogen, and factor VIII were not associated with occurrence of cognitive impairment after multivariable adjustment; however, having at least 2 abnormal biomarkers was associated, suggesting the burden of these biomarkers is relevant.
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11 citations in Scopus
Details
- Title
- Hemostasis biomarkers and incident cognitive impairment: the REGARDS study
- Creators
- Sr GillettLa McclurePw CallasEl ThackerFw UnverzagtVg WadleyAj LetterM. Cushman - University of Vermont
- Publication Details
- Journal of thrombosis and haemostasis, v 16(7), pp 1259-1267
- Publisher
- Wiley
- Resource Type
- Other
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000437289500004
- Scopus ID
- 2-s2.0-85049525530
- Other Identifier
- 991019169015504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology
- Peripheral Vascular Disease