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ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport-Mediated PK and DDIs in Humans
Clinical pharmacology and therapeutics, v 94(1)
25 Feb 2013
PMID: 23588311
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This white paper provides a critical analysis of methods for estimating
transporter kinetics and recommendations on proper parameter calculation in
various experimental systems. Rational interpretation of transporter-knockout
animal findings and application of static and dynamic physiologically based
modeling approaches for prediction of human transporter-mediated
pharmacokinetics and drug–drug interactions (DDIs) are presented. The
objective is to provide appropriate guidance for the use of in
vitro, in vivo, and modeling tools in
translational transporter science.
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182 citations in Scopus
Details
- Title
- ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport-Mediated PK and DDIs in Humans
- Creators
- Mj Zamek-GliszczynskiCa LeeA. Poirier - RocheJ. Bentz - Drexel UniversityX. Chu - MSDH. Ellens - GlaxoSmithKlineT. Ishikawa - RIKEN Center for Integrative Medical SciencesM. Jamei - SimcypJc Kalvass - Experimental Kinetics and Analysis, Abbott Laboratories Abbott Park Illinois USAS. Nagar - Temple UniversityKs Pang - University of TorontoK. Korzekwa - Temple UniversityPw SwaanMe TaubP. Zhao - Center for Drug Evaluation and ResearchA. Galetin - University of ManchesterInt Transporter Consortium
- Publication Details
- Clinical pharmacology and therapeutics, v 94(1)
- Publisher
- Springer Nature
- Resource Type
- Other
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000321028500014
- Scopus ID
- 2-s2.0-84879416924
- Other Identifier
- 991019168543204721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pharmacology & Pharmacy