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Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia-thalamic communication
bioRxiv
26 Aug 2020
Abstract
Task-related activity in the ventral thalamus, a major target of basal ganglia output, is often assumed to be permitted or triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms. To test those hypotheses, we sampled single-unit activity from connected basal ganglia output and thalamic nuclei (globus pallidus-internus, GPi, and ventrolateral-anterior nucleus, VLa) in monkeys performing a reaching task. Rate increases were the most common peri-movement change in both nuclei. Moreover, peri-movement changes generally began earlier in VLa than in GPi. Simultaneously-recorded GPi-VLa pairs rarely showed short-timescale spike-to-spike correlations or slow across-trials covariations and both were equally positive and negative. Finally, spontaneous GPi bursts and pauses were both followed by small, slow reductions in VLa rate. These results appear incompatible with standard gating and rebound models. Still, gating or rebound may be possible in other physiological situations: Simulations show how GPi-VLa communication can scale with GPi synchrony and GPi-to-VLa convergence, illuminating how synchrony of basal ganglia output during motor learning or in pathological conditions may render this pathway effective. Thus, in the healthy state, basal ganglia-thalamic communication during learned movement is more subtle than expected, with changes in firing rates possibly being dominated by a common external source. Competing Interest Statement The authors have declared no competing interest. Footnotes * https://doi.org/10.5061/dryad.0cfxpnvxm
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Details
- Title
- Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia-thalamic communication
- Creators
- Bettina Schwab - University Medical Center Hamburg-EppendorfDaisuke Kase - University of PittsburghAndrew Zimnik - Columbia University Irving Medical CenterRobert Rosenbaum - University of Notre DameMarcello Codianni - University of PittsburghJonathan Rubin - University of PittsburghRobert Turner - University of Pittsburgh
- Publication Details
- bioRxiv
- Publisher
- Cold Spring Harbor Laboratory Press; Cold Spring Harbor
- Resource Type
- Other
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Other Identifier
- 991019415662104721