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Social isolation potentiates cell death and inflammatory responses after global ischemia
Other   Open access   Peer reviewed

Social isolation potentiates cell death and inflammatory responses after global ischemia

Zm Weil, Gj Norman, Jm Barker, Aj Su, Rj Nelson and Ac Devries
Molecular psychiatry, v 13(10), pp 913-915
01 Oct 2008
DOI: https://doi.org/10.1038/mp.2008.70
PMID: 18800053
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc2612576?pdf=renderView
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Article
Social integration is fundamental for good emotional and physical health. Indeed, socially isolated individuals with low perceived social support are at increased risk for many health conditions (reviewed in references Hawkley and Cacioppo1 and House et al.2), including cardiovascular disease.3, 4, 5 Development of animal models is required to understand the specific physiological mechanisms responsible for the effects of social isolation on health. Here, we provide evidence that social isolation in mice potentiates the pathophysiological responses to cardiac arrest (CA), which may explain, in part, why social isolation is as strong a predictor of 1-year mortality among acute myocardial infarction patients as some of the classic physiological risk factors, including high blood cholesterol concentrations and hypertension.5

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Web of Science research areas
Biochemistry & Molecular Biology
Neurosciences
Psychiatry
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