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Brisc deubiquitinating enzyme inhibitors
Patent   Open access

Brisc deubiquitinating enzyme inhibitors

Elton Zeqiraj, Frank Sicheri, Roger Greenberg and Joseph M Salvino
06 Jun 2024
url
https://patents.google.com/patent/WO2024115713A1View
Published, Version of Record (VoR)Open Access (License Unspecified) Open

Abstract

CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS Metallurgy Organic Chemistry
The present disclosure provides for techniques using BRISC deubiquitinating enzyme inhibitors of formula (I) for treating and/ or preventing systemic lupus erythematosus (SLE). Accordingly, the present disclosure provides for compositions and methods for treating or preventing a disease or disorder mediated by inhibition of type I interferon receptor (IFNAR1) signaling.

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