Patent
Methods and compositions for re-activating Epstein-Barr virus and screening compounds therefor
04 Jun 2019
Abstract
In an effort to discover therapies for treating diseases caused by EBV, a novel screening assay for identifying compounds that reactivate EBV latent infection and a family of small molecules based on a tetrahydrocarboline backbone were discovered. Specifically, the compounds have the structure of the formula (I), wherein R1-R11 are defined herein and activate/reactivate EBV in a variety of cell types in a patient and are, therefore, useful in preventing or treating EBV-positive cancer, optionally with an anti-viral agent. In screening these compounds, novel compositions, EBV-positive cell lines, and methods are provided. (Formula I)
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Details
- Title
- Methods and compositions for re-activating Epstein-Barr virus and screening compounds therefor
- Creators
- Paul M Lieberman - The Wistar InstituteNadezhda Tikhmyanova-EckertJoseph M Salvino
- Resource Type
- Patent
- Language
- English
- Patent
- US20190240202A1; A1
- Academic Unit
- Pharmacology and Physiology
- Identifiers
- 991021904613204721