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Modulators of Excitatory Amino Acid Transporters and Methods Using Same
Patent   Open access

Modulators of Excitatory Amino Acid Transporters and Methods Using Same

Valli Venkata Srikanth Yellamelli, Andreia C.K Mortensen and Joseph M Salvino
25 Aug 2022
url
https://patents.google.com/patent/WO2021011876A2View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS Metallurgy Organic Chemistry
The present disclosure provides in one aspect compounds of Formula I. In certain embodiments, the compounds of the disclosure are useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compounds of the disclosure stimulate a glutamate transporter.

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