Patent
Sigma receptor ligands and methods of modulating cellular protein homeostasis using same
11 Jun 2019
Abstract
The present invention includes compounds useful in preventing, treating or ameliorating Sigma-related disorders or diseases. The compounds of the invention may modulate cellular protein homeostasis, which includes: translation initiation, folding, processing, transport, and degradation (including ubiquitin selective autophagy) of proteins. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound. The present invention also includes methods of preventing, treating or ameliorating a Sigma-related disorder or disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a Sigma-modulating compound, further comprising administering an effective amount of a compound that inhibits the ubiquitin proteasome system (UPS) and/or autophagic survival pathways.
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Details
- Title
- Sigma receptor ligands and methods of modulating cellular protein homeostasis using same
- Creators
- Joseph M SalvinoFelix J Kim
- Resource Type
- Patent
- Language
- English
- Patent
- US10314795B2; B2
- Academic Unit
- Pharmacology and Physiology
- Identifiers
- 991021904613104721