Patent
Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
08 Mar 2022
Abstract
The disclosure provides compounds of formula (I) having the structure:Compounds of formula (I) are fractalkine receptor agonists and useful in treating, preventing or minimizing metastasis in a subject diagnosed with cancer. The compounds of the invention are further useful in treating central nervous system diseases (such as, but not limited to, HIV Associated Neurocognitive Disorders (HAND), and/or Alzheimer's disease), pain, inflammation (such as, but not limited to, arthritis), cardiovascular disease (such as, but not limited to, undesired vascular smooth muscle proliferation, atherosclerosis, coronary vascular endothelial dysfunction, and/or coronary artery disease), and/or multiple sclerosis.
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Details
- Title
- Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
- Creators
- Joseph M SalvinoXin FengAlessandro Fatatis - Drexel University, Pharmacology and PhysiologyOlimpia Meucci - Drexel University, Pharmacology and PhysiologyFei Shen - Drexel University
- Resource Type
- Patent
- Language
- English
- Patent
- US11267817B2; B2
- Academic Unit
- Pharmacology and Physiology
- Identifiers
- 991021904613904721