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Preprint
A percolation-type criticality threshold controls immune protein coating of surfaces
bioRxiv
18 Oct 2024
PMID: 39464129
Abstract
When a material enters the body, it is immediately attacked by hundreds of proteins, organized into complex networks of binding interactions and reactions. How do such complex systems interact with a material, "deciding" whether to attack? We focus on the "complement" system of ∼40 blood proteins that bind microbes, nanoparticles, and medical devices, initiating inflammation. We show a sharp threshold for complement activation upon varying a fundamental material parameter, the surface density of potential complement attachment points. This sharp threshold manifests at scales spanning single nanoparticles to macroscale pathologies, shown here for diverse engineered and living materials. Computational models show these behaviors arise from a minimal subnetwork of complement, manifesting percolation-type critical transitions in the complement response. This criticality switch explains the "decision" of a complex signaling network to interact with a material, and elucidates the evolution and engineering of materials interacting with the body.When a material enters the body, it is immediately attacked by hundreds of proteins, organized into complex networks of binding interactions and reactions. How do such complex systems interact with a material, "deciding" whether to attack? We focus on the "complement" system of ∼40 blood proteins that bind microbes, nanoparticles, and medical devices, initiating inflammation. We show a sharp threshold for complement activation upon varying a fundamental material parameter, the surface density of potential complement attachment points. This sharp threshold manifests at scales spanning single nanoparticles to macroscale pathologies, shown here for diverse engineered and living materials. Computational models show these behaviors arise from a minimal subnetwork of complement, manifesting percolation-type critical transitions in the complement response. This criticality switch explains the "decision" of a complex signaling network to interact with a material, and elucidates the evolution and engineering of materials interacting with the body.
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Details
- Title
- A percolation-type criticality threshold controls immune protein coating of surfaces
- Creators
- Zhicheng Wang - University of PennsylvaniaSahil Kulkarni - University of PennsylvaniaJia Nong - University of PennsylvaniaMarco Zamora - University of PennsylvaniaAlireza Ebrahimimojarad - Drexel UniversityElizabeth Hood - University of PennsylvaniaTea Shuvaeva - University of PennsylvaniaMichael Zaleski - University of PennsylvaniaDamodar Gullipalli - University of PennsylvaniaEmily Wolfe - University of PennsylvaniaCarolann Espy - University of PennsylvaniaEvguenia Arguiri - University of PennsylvaniaYufei Wang - University of PennsylvaniaOscar A Marcos-Contreras - University of PennsylvaniaWenchao Song - University of PennsylvaniaVladimir R Muzykantov - University of PennsylvaniaJinglin Fu - Rutgers University–CamdenRavi Radhakrishnan - University of PennsylvaniaJacob W Myerson - University of PennsylvaniaJacob S Brenner - University of Pennsylvania
- Publication Details
- bioRxiv
- Publisher
- American Physical Society (APS)
- Resource Type
- Preprint
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Other Identifier
- 991021932215604721