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Preprint
Network Controllability in the IFG Relates to Controlled Language Variability and Susceptibility to TMS
14 Sep 2017
Abstract
In language production, humans are confronted with considerable word
selection demands. Often, we must select a word from among similar, acceptable,
and competing alternative words in order to construct a sentence that conveys
an intended meaning. In recent years, the left inferior frontal gyrus (LIFG)
has been identified as critical to this ability. Despite a recent emphasis on
network approaches to understanding language, how the LIFG interacts with the
brain's complex networks to facilitate controlled language performance remains
unknown. Here, we take a novel approach to understand word selection as a
network control process in the brain. Using an anatomical brain network derived
from high-resolution diffusion spectrum imaging (DSI), we computed network
controllability underlying the site of transcranial magnetic stimulation in the
LIFG between administrations of two word selection tasks. We find that a
statistic that quantifies the LIFG's theoretically predicted control of
difficult-to-reach states explains vulnerability to TMS in language tasks that
vary in response (cognitive control) demands: open-response (word generation)
vs. closed-response (number naming) tasks. Moreover, we find that a statistic
that quantifies the LIFG's theoretically predicted control of communication
across modules in the human connectome explains TMS-induced changes in
open-response language task performance only. These findings establish a link
between network controllability, cognitive function, and TMS effects.
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Details
- Title
- Network Controllability in the IFG Relates to Controlled Language Variability and Susceptibility to TMS
- Creators
- John D MedagliaDenise Y HarveyNicole WhiteDanielle S BassettRoy H Hamilton
- Resource Type
- Preprint
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Other Identifier
- 991019296760404721