Preprint
YAP/TAZ signaling in allantois-derived cells is required for placental vascularization
bioRxiv
16 Sep 2024
PMID: 39345443
Abstract
Normal placental development and angiogenesis are crucial for fetal growth and maternal health during pregnancy. However, molecular regulation of placental angiogenesis has been difficult to study due to a lack of specific genetic tools that isolate the placenta from the embryo and yolk sac. To address this gap in knowledge we recently developed Hoxa13Cre mice in which Cre is expressed in allantois-derived cells, including placental endothelial and stromal cells. Mice lacking the transcriptional regulators Yes-associated protein (YAP) and PDZ-binding motif (TAZ) in allantois-derived cells exhibit embryonic lethality at midgestation with compromised placental vasculature. snRNA-seq analysis revealed transcriptional changes in placental stromal cells and endothelial cells. YAP/TAZ mutants exhibited significantly reduced placental stromal cells prior to the endothelial architectural change, highlighting the role of these cells in placental vascular growth. These results reveal a central role for YAP/TAZ signaling during placental vascular growth and implicate Hoxa13-derived placental stromal cells as a critical component of placental vascularization.
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Details
- Title
- YAP/TAZ signaling in allantois-derived cells is required for placental vascularization
- Creators
- Siqi Gao - University of PennsylvaniaTriloshan Thillaikumaran - University of PennsylvaniaMartin H. Dominguez - University of PennsylvaniaWilliam Giang - Pennsylvania State UniversityKevin Hayes - University of PennsylvaniaXiaowen Chen - University of PennsylvaniaJesse Pace - University of PennsylvaniaJenna Bockman - University of PennsylvaniaDanielle Jathan - University of PennsylvaniaDerek Sung - University of PennsylvaniaSweta Narayan - University of PennsylvaniaMaxwell Frankfurter - University of PennsylvaniaPatricia Mericko-Ishizuka - University of PennsylvaniaJisheng Yang - University of PennsylvaniaMarco Castro - Charité - Universitätsmedizin BerlinMichael Potente - Charité - Universitätsmedizin BerlinMark L. Kahn - University of Pennsylvania
- Publication Details
- bioRxiv
- Publisher
- Cold Spring Harbor Laboratory
- Edition
- 1.1
- Number of pages
- 23
- Resource Type
- Preprint
- Language
- English
- Academic Unit
- General Internal Medicine
- Other Identifier
- 991022054323004721