Protein interactions in health and disease, structure-based antagonism of HIV-1 Env, recombinant protein/peptidomimetic/small molecule inhibitor design and mechanism of action.
Our research program is centered on molecular and structural mechanisms of protein recognition and antagonism. The major current focus is on the protein machine that controls HIV-1 cell entry into host cells. We investigate interactions of the viral envelope proteins with host cell receptor proteins using a multidisciplinary approach combining protein chemistry, molecular biology and biophysical tools.